Sam, 41, interjected Angela Cox’s entertainment segment on the lawyer’s recent birth of twins, Ella and Alexander.
‘Come on — I bet she’s already back to her pre-pregnancy weight today,’ she joked.
Mother-of-two Natalie, 49, then quipped: ‘By lunch time!’
The pair also spoke about what Amal’s parenting style would be like.
‘As if Amal would yell,’ Sam suggested humorously.
But David defended the brunette beauty and told the girls they were being ‘nasty’.
‘Now you girls. Give her a break,’ he teased.
‘You’re being nasty. No, I think she’ll be a lovely mother.’
Screwing up her face, Natalie insisted to Kochie that the pair were merely kidding around.
‘We’re not being nasty. We were joking!’ she exclaimed.
Amal, 39, gave birth to a girl, Ella, and a boy, Alexander, on Tuesday morning in England.
‘This morning Amal and George welcomed Ella and Alexander Clooney into their lives,’ a spokesperson for the 56-year-old actor said in a statement.
‘Ella, Alexander and Amal are all healthy, happy and doing fine.’
Earlier this year on Sunrise while discussing post-Oscar shenanigans with entertainment reporter Aspen, talk turned to celebrities indulging in junk food after following a strict red carpet diet.
‘As if any of those people eat doughnuts?! I mean c’mon,’ Samantha said, next to a bemused David.
‘Let’s be serious here for a minute,’ she continued.
‘After a lot of drinks they do,’ Nelson interjected, to which Samantha added in jest: ‘They probably go home and vomit them all up.’